Seroatlas · Human Serome Atlas

ALOX15B

Polyunsaturated fatty acid lipoxygenase ALOX15B

Also known as: 15-LOX-2, LX15B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15296
Gene
ALOX15B
Ensembl
ENSG00000179593
Chromosome
17
Canonical length
676 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>O15296|ALOX15B
     1  MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED
    61  VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE
   121  GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK
   181  NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS
   241  QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT
   301  NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV
   361  RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL
   421  IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI
   481  WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ
   541  YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT
   601  CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL
   661  PYTYLDPPLI ENSVSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALOX15B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • breast: 105 nTPM
  • prostate: 69 nTPM
  • esophagus: 38 nTPM
  • skin: 36 nTPM
  • vagina: 33 nTPM
  • lung: 24 nTPM

Single-cell type

  • alveolar cells type 2: 251 nCPM
  • esophageal suprabasal cells: 128 nCPM
  • prostatic glandular cells: 100 nCPM
  • conjunctival goblet cells: 72 nCPM
  • esophageal apical cells: 71 nCPM
  • transitional alveolar cells: 64 nCPM

Immune cell

  • myeloid DC: 4.3 nTPM
  • classical monocyte: 3.9 nTPM
  • total PBMC: 0.9 nTPM
  • NK-cell: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • white matter: 3.4 nTPM
  • medulla oblongata: 3.2 nTPM
  • pons: 2.3 nTPM
  • thalamus: 1.5 nTPM
  • spinal cord: 1.3 nTPM
  • hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALOX15B as an antibody target. Whether an autoantibody or antibody against ALOX15B could matter depends on whether native ALOX15B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALOX15B is annotated at the cell surface, where native ALOX15B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ALOX15B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALOX15B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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