Seroatlas · Human Serome Atlas

PNLIPRP1

Inactive pancreatic lipase-related protein 1

Also known as: LIPR1_HUMAN, PLRP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54315
Gene
PNLIPRP1
Ensembl
ENSG00000187021
Chromosome
10
Canonical length
467 aa
Protein class
Metabolic proteins, Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

Predicted to enable calcium ion binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to be located in extracellular region. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>P54315|PNLIPRP1
     1  MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE KIGTRFLLYT
    61  NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG DESWVTDMCK KLFEVEEVNC
   121  ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM LDILLTEYSY PPSKVHLIGH SLGAHVAGEA
   181  GSKTPGLSRI TGLDPVEASF ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG
   241  HLDFFPNGGE SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
   301  YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA SNFARWRYGV
   361  SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH SYEFDAKLDV GTIEKVKFLW
   421  NNNVINPTLP KVGATKITVQ KGEEKTVYNF CSEDTVREDT LLTLTPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNLIPRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
10,208 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 10,208 nTPM
  • salivary gland: 2.6 nTPM
  • blood vessel: 2 nTPM
  • duodenum: 2 nTPM
  • heart muscle: 1.9 nTPM
  • ovary: 1.8 nTPM

Single-cell type

  • pancreatic acinar cells: 7,209 nCPM
  • pancreatic duct cells: 52 nCPM
  • monocytes: 10 nCPM
  • late spermatids: 5.1 nCPM
  • pancreatic islet cells: 3.4 nCPM
  • macrophages: 2.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
-0.08
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNLIPRP1 as an antibody target. Whether an autoantibody or antibody against PNLIPRP1 could matter depends on whether native PNLIPRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNLIPRP1 is annotated as secreted, so native PNLIPRP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PNLIPRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PNLIPRP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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