Seroatlas · Human Serome Atlas

PNLIPRP3

Pancreatic lipase-related protein 3

Also known as: LIPR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RR3
Gene: PNLIPRP3
Ensembl: ENSG00000203837
Chromosome: 10
Canonical length: 467 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q17RR3|PNLIPRP3
     1  MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE KINTRFLLYT
    61  IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG KWQRDMCNVL LQLEDINCIN
   121  LDWINGSREY IHAVNNLRVV GAEVAYFIDV LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR
   181  IPGLGRITGL DPAGPFFHNT PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD
   241  FYPNGGKHMP GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
   301  CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS PFARWRHKLS
   361  VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY TKLIDADVNV GNITSVQFIW
   421  KKHLFEDSQN KLGAEMVINT SGKYGYKSTF CSQDIMGPNI LQNLKPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNLIPRP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skin: 13 nTPM
breast: 8.5 nTPM
vagina: 2.9 nTPM
esophagus: 2.3 nTPM
cervix: 2.2 nTPM
adipose tissue: 2.1 nTPM

Single-cell type

esophageal apical cells: 60 nCPM
suprabasal keratinocytes: 16 nCPM
basal keratinocytes: 9.8 nCPM
early spermatids: 7 nCPM
pancreatic acinar cells: 5.9 nCPM
late spermatids: 3.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNLIPRP3 as an antibody target. Whether an autoantibody or antibody against PNLIPRP3 could matter depends on whether native PNLIPRP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNLIPRP3 is annotated as secreted, so native PNLIPRP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PNLIPRP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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