Seroatlas · Human Serome Atlas

LIPC

Hepatic triacylglycerol lipase

Also known as: HL, HTGL, LIPC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11150
Gene: LIPC
Ensembl: ENSG00000166035
Chromosome: 15
Canonical length: 499 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phospholipase A1 activity and triacylglycerol lipase activity. Involved in several processes, including cholesterol homeostasis; plasma lipoprotein particle remodeling; and triglyceride catabolic process. Located in extracellular space. Implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Biomarker of hyperinsulinism; obesity; and type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>P11150|LIPC
     1  MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT RFLLFGETNQ
    61  GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI WQMVAALKSQ PAQPVNVGLV
   121  DWITLAHDHY TIAVRNTRLV GKEVAALLRW LEESVQLSRS HVHLIGYSLG AHVSGFAGSS
   181  IGGTHKIGRI TGLDAAGPLF EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH
   241  YDFYPNGGSF QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
   301  PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK VYHYQFKIQF
   361  INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY SFLITLDVDI GELIMIKFKW
   421  ENSAVWANVW DTVQTIIPWS TGPRHSGLVL KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ
   481  EKIFVKCEIK SKTSKRKIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

liver: 160 nTPM
kidney: 5.6 nTPM
pancreas: 2.3 nTPM
thymus: 2 nTPM
spinal cord: 1.9 nTPM
duodenum: 1.7 nTPM

Single-cell type

hepatocytes: 303 nCPM
papillary tip epithelial cells: 89 nCPM
renal collecting duct principal cells: 77 nCPM
microglia: 70 nCPM
loop of henle epithelial cells: 48 nCPM
renal connecting tubule cells: 43 nCPM

Immune cell

MAIT T-cell: 1.8 nTPM
basophil: 1.7 nTPM
NK-cell: 1.5 nTPM
gdT-cell: 1.3 nTPM
naive CD8 T-cell: 1.3 nTPM
total PBMC: 1.1 nTPM

Brain region

white matter: 3.6 nTPM
pons: 3.4 nTPM
cerebral cortex: 3.1 nTPM
cerebellum: 2.9 nTPM
medulla oblongata: 2.9 nTPM
midbrain: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LIPC.

Disease | AllUniProt

Conditions LIPC is implicated in, by any mechanism.

Hepatic lipase deficiency (HL deficiency) MIM:614025

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 349 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hyperlipidemia due to hepatic triglyceride lipase deficiency
Abnormal circulating lipid concentration
Cervical cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: -0.92
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPC as an antibody target. Whether an autoantibody or antibody against LIPC could matter depends on whether native LIPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPC is annotated as secreted, so native LIPC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LIPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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