Seroatlas · Human Serome Atlas

PNLIPRP2

Pancreatic lipase-related protein 2

Also known as: LIPR2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54317
Gene: PNLIPRP2
Canonical length: 469 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PNLIPRP2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>P54317|PNLIPRP2
     1  MLPPWTLGLL LLATVRGKEV CYGQLGCFSD EKPWAGTLQR PVKLLPWSPE DIDTRFLLYT
    61  NENPNNFQLI TGTEPDTIEA SNFQLDRKTR FIIHGFLDKA EDSWPSDMCK KMFEVEKVNC
   121  ICVDWRHGSR AMYTQAVQNI RVVGAETAFL IQALSTQLGY SLEDVHVIGH SLGAHTAAEA
   181  GRRLGGRVGR ITGLDPAGPC FQDEPEEVRL DPSDAVFVDV IHTDSSPIVP SLGFGMSQKV
   241  GHLDFFPNGG KEMPGCKKNV LSTITDIDGI WEGIGGFVSC NHLRSFEYYS SSVLNPDGFL
   301  GYPCASYDEF QESKCFPCPA EGCPKMGHYA DQFKGKTSAV EQTFFLNTGE SGNFTSWRYK
   361  ISVTLSGKEK VNGYIRIALY GSNENSKQYE IFKGSLKPDA SHTCAIDVDF NVGKIQKVKF
   421  LWNKRGINLS EPKLGASQIT VQSGEDGTEY NFCSSDTVEE NVLQSLYPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNLIPRP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 8,150 nTPM

Expression across tissuesHPA

Tissue

pancreas: 8,150 nTPM
small intestine: 75 nTPM
duodenum: 61 nTPM
rectum: 17 nTPM
stomach: 7.5 nTPM
colon: 7 nTPM

Single-cell type

pancreatic acinar cells: 2,695 nCPM
enterocytes: 209 nCPM
enteric transient amplifying cells: 30 nCPM
pancreatic duct cells: 29 nCPM
enteric stem cells: 29 nCPM
colonocytes: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 0.2 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.22

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNLIPRP2 as an antibody target. Whether an autoantibody or antibody against PNLIPRP2 could matter depends on whether native PNLIPRP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNLIPRP2 is annotated as secreted, so native PNLIPRP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PNLIPRP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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