Kunitz/Bovine pancreatic trypsin inhibitor domain
PF00014
Definition
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, [swissprot:P17726]). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways PMID:7925983. TAP molecules are highly dipolar PMID:10716178, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix PMID:7925983.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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