Seroatlas · Human Serome Atlas

COL28A1

Collagen alpha-1(XXVIII) chain

Also known as: COSA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2UY09
Gene: COL28A1
Ensembl: ENSG00000215018
Chromosome: 7
Canonical length: 1125 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to extracellular matrix
Quaternary structure: Homotrimer

OverviewNCBI Gene

COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

1125 residues, UniProt reviewed canonical sequence.

>Q2UY09|COL28A1
     1  MWNRYFVFYL LLLSAFTSQT VSGQRKKGPK SNLLARKSDV QGSICFIDIV FIVDSSESSK
    61  IALFDKQKDF VDSLSDKIFQ LTPGRSLEYD IKLAALQFSS SVQIDPPFSS WKDLQTFKQK
   121  VKSMNLIGQG TFSYYAISNA TRLLKREGRK DGVKVVLLMT DGIDHPKNPD VQSISEDARI
   181  SGISFITIAL STVVNEAKLR LISGDSSSEP TLLLSDPTLV DKIQDRLDIL FEKKCERKIC
   241  ECEKGDPGDP GPPGTHGNPG IKGERGPKGN PGNAQKGEAG ERGPGGIPGY KGDKGERGEC
   301  GKPGIKGDKG SPGPYGPKGP RGIQGITGPP GDPGPKGFQG NKGEPGPPGP YGSPGAPGIG
   361  QQGIKGERGQ EGRPGAPGPI GVGEPGQPGP RGPEGVPGER GLPGEGFPGP KGEKGSEGPT
   421  GPQGLQGLSI KGEKGDIGPV GPQGPMGIPG IGSQGEQGIQ GPIGPPGPQG PAGQGLPGSK
   481  GEVGQMGPTG PRGPVGIGVQ GPKGEPGSIG LPGQPGVPGE DGAAGKKGEA GLPGARGPEG
   541  PPGKGQPGPK GDEGKKGSKG NQGQRGLPGP EGPKGEPGIM GPFGMPGTSI PGPPGPKGDR
   601  GGPGIPGFKG EPGLSIRGPK GVQGPRGPVG APGLKGDGYP GVPGPRGLPG PPGPMGLRGV
   661  GDTGAKGEPG VRGPPGPSGP RGVGTQGPKG DTGQKGLPGP PGPPGYGSQG IKGEQGPQGF
   721  PGPKGTMGHG LPGQKGEHGE RGDVGKKGDK GEIGEPGSPG KQGLQGPKGD LGLTKEEIIK
   781  LITEICGCGP KCKETPLELV FVIDSSESVG PENFQIIKNF VKTMADRVAL DLATARIGII
   841  NYSHKVEKVA NLKQFSSKDD FKLAVDNMQY LGEGTYTATA LQAANDMFED ARPGVKKVAL
   901  VITDGQTDSR DKEKLTEVVK NASDTNVEIF VIGVVKKNDP NFEIFHKEMN LIATDPEHVY
   961  QFDDFFTLQD TLKQKLFQKI CEDFDSYLVQ IFGSSSPQPG FGMSGEELSE STPEPQKEIS
  1021  ESLSVTRDQD EDDKAPEPTW ADDLPATTSS EATTTPRPLL STPVDGAEDP RCLEALKPGN
  1081  CGEYVVRWYY DKQVNSCARF WFSGCNGSGN RFNSEKECQE TCIQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COL28A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 17 nTPM
epididymis: 14 nTPM
colon: 11 nTPM
pituitary gland: 10 nTPM
retina: 6.3 nTPM
stomach: 6.1 nTPM

Single-cell type

schwann cells: 444 nCPM
corticotrophs: 379 nCPM
thymic myoid cells: 284 nCPM
ependymal cells: 247 nCPM
lacrimal acinar cells: 232 nCPM
respiratory ciliated cells: 208 nCPM

Immune cell

neutrophil: 0.5 nTPM
NK-cell: 0.4 nTPM
basophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

midbrain: 20 nTPM
cerebral cortex: 18 nTPM
cerebellum: 17 nTPM
white matter: 16 nTPM
hypothalamus: 15 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.88
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COL28A1 as an antibody target. Whether an autoantibody or antibody against COL28A1 could matter depends on whether native COL28A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COL28A1 is annotated as secreted, so native COL28A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COL28A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...