SPINT4
Kunitz-type protease inhibitor 4
Also known as: C20orf137, dJ601O1.1, SPIT4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UDR6
- Gene
- SPINT4
- Ensembl
- ENSG00000149651
- Chromosome
- 20
- Canonical length
- 99 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q6UDR6|SPINT4
1 MKSAKLGFLL RFFIFCSLNT LLLGGVNKIA EKICGDLKDP CKLDMNFGSC YEVHFRYFYN
61 RTSKRCETFV FSGCNGNLNN FKLKIEREVA CVAKYKPPRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPINT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 263 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 263 nTPM
- retina: 1 nTPM
- seminal vesicle: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- epididymal principal cells: 573 nCPM
- rod photoreceptor cells: 94 nCPM
- retinal ganglion cells: 12 nCPM
- epididymal basal cells: 6.7 nCPM
- cone photoreceptor cells: 6.2 nCPM
- retinal horizontal cells: 6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 0.9 nTPM
- spinal cord: 0.9 nTPM
- white matter: 0.6 nTPM
- medulla oblongata: 0.5 nTPM
- pons: 0.4 nTPM
- basal ganglia: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.38
- gnomAD pLI
- 0.08
- gnomAD missense Z
- 0.33
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPINT4 as an antibody target. Whether an autoantibody or antibody against SPINT4 could matter depends on whether native SPINT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPINT4 is annotated as secreted, so native SPINT4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPINT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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