Seroatlas · Human Serome Atlas

WFIKKN2

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Also known as: WFDC20B, WFIKKNRP, WFKN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TEU8
Gene
WFIKKN2
Ensembl
ENSG00000173714
Chromosome
17
Canonical length
576 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q8TEU8|WFIKKN2
     1  MWAPRCRRFW SRWEQVAALL LLLLLLGVPP RSLALPPIRY SHAGICPNDM NPNLWVDAQS
    61  TCRRECETDQ ECETYEKCCP NVCGTKSCVA ARYMDVKGKK GPVGMPKEAT CDHFMCLQQG
   121  SECDIWDGQP VCKCKDRCEK EPSFTCASDG LTYYNRCYMD AEACSKGITL AVVTCRYHFT
   181  WPNTSPPPPE TTMHPTTASP ETPELDMAAP ALLNNPVHQS VTMGETVSFL CDVVGRPRPE
   241  ITWEKQLEDR ENVVMRPNHV RGNVVVTNIA QLVIYNAQLQ DAGIYTCTAR NVAGVLRADF
   301  PLSVVRGHQA AATSESSPNG TAFPAAECLK PPDSEDCGEE QTRWHFDAQA NNCLTFTFGH
   361  CHRNLNHFET YEACMLACMS GPLAACSLPA LQGPCKAYAP RWAYNSQTGQ CQSFVYGGCE
   421  GNGNNFESRE ACEESCPFPR GNQRCRACKP RQKLVTSFCR SDFVILGRVS ELTEEPDSGR
   481  ALVTVDEVLK DEKMGLKFLG QEPLEVTLLH VDWACPCPNV TVSEMPLIIM GEVDGGMAML
   541  RPDSFVGASS ARRVRKLREV MHKKTCDVLK EFLGLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WFIKKN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
1,103 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 1,103 nTPM
  • ovary: 144 nTPM
  • pituitary gland: 2.2 nTPM
  • testis: 2.2 nTPM
  • skeletal muscle: 2 nTPM
  • cerebellum: 1.9 nTPM

Single-cell type

  • peritubular myoid cells: 22 nCPM
  • ovarian stromal cells: 22 nCPM
  • leydig cells: 9.3 nCPM
  • oocytes: 9.2 nCPM
  • granulosa cells: 6.5 nCPM
  • choroid plexus epithelial cells: 4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 1,253 nTPM
  • hippocampal formation: 18 nTPM
  • thalamus: 11 nTPM
  • cerebellum: 11 nTPM
  • amygdala: 4.8 nTPM
  • white matter: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.21
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WFIKKN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WFIKKN2 as an antibody target. Whether an autoantibody or antibody against WFIKKN2 could matter depends on whether native WFIKKN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WFIKKN2 is annotated as secreted, so native WFIKKN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WFIKKN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WFIKKN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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