7 transmembrane sweet-taste receptor of 3 GCPR
PF00003
Definition
This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G [pfam:PF07562], which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor [pfam:PF01094]. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness PMID:16076846.
22 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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