TAS1R3

Protein identityUniProt · HPA

UniProt accession

Q7RTX0

Gene

TAS1R3

Ensembl

ENSG00000169962

Chromosome

1

Canonical length

852 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Golgi apparatus,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q7RTX0|TAS1R3
     1  MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG LRSRTRPSSP
    61  VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF DTCSEPVVAM KPSLMFLAKA
   121  GSRDIAAYCN YTQYQPRVLA VIGPHSSELA MVTGKFFSFF LMPQVSYGAS MELLSARETF
   181  PSFFRTVPSD RVQLTAAAEL LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE
   241  GLVPLPRADD SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
   301  EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF CSALGEREQG
   361  LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV AQALHNTLQC NASGCPAQDP
   421  VKPWQLLENM YNLTFHVGGL PLRFDSSGNV DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT
   481  ERLKIRWHTS DNQKPVSRCS RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF
   541  CGQDEWSPER STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
   601  ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST LFLQAAEIFV
   661  ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL VAFPPEVVTD WHMLPTEALV
   721  HCRTRSWVSF GLAHATNATL AFLCFLGTFL VRSQPGCYNR ARGLTFAMLA YFITWVSFVP
   781  LLANVQVVLR PAVQMGALLL CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ
   841  NDGNTGNQGK HE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS1R3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.56

gnomAD pLI

0

gnomAD missense Z

-2.38

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detection of chemical stimulus involved in sensory perception of sweet taste
• G protein-coupled receptor signaling pathway
• sensory perception of sweet taste
• sensory perception of umami taste

Molecular functions

• G protein-coupled receptor activity
• taste receptor activity

Cellular components

• Golgi apparatus
• membrane
• plasma membrane
• sweet taste receptor complex

Protein domainsUniProt · Pfam · InterPro

• GPCR, family 3, extracellular calcium-sensing receptor-related
• GPCR, family 3
• Receptor, ligand binding region
• GPCR, family 3, nine cysteines domain
• GPCR family 3, C-terminal
• GPCR, family 3, conserved site
• Periplasmic binding protein-like I
• GPCR, family 3, nine cysteines domain superfamily
• 7 transmembrane sweet-taste receptor of 3 GCPR
• Receptor family ligand binding region
• Nine Cysteines Domain of family 3 GPCR

KeywordsUniProt

• Cell membrane
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Sensory transduction
• Signal
• Taste
• Transducer
• Transmembrane
• Transmembrane helix