Seroatlas · Human Serome Atlas

GPRC5B

G-protein coupled receptor family C group 5 member B

Also known as: GPC5B_HUMAN, RAIG-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZH0
Gene: GPRC5B
Ensembl: ENSG00000167191
Chromosome: 16
Canonical length: 403 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q9NZH0|GPRC5B
     1  MFVASERKMR AHQVLTFLLL FVITSVASEN ASTSRGCGLD LLPQYVSLCD LDAIWGIVVE
    61  AVAGAGALIT LLLMLILLVR LPFIKEKEKK SPVGLHFLFL LGTLGLFGLT FAFIIQEDET
   121  ICSVRRFLWG VLFALCFSCL LSQAWRVRRL VRHGTGPAGW QLVGLALCLM LVQVIIAVEW
   181  LVLTVLRDTR PACAYEPMDF VMALIYDMVL LVVTLGLALF TLCGKFKRWK LNGAFLLITA
   241  FLSVLIWVAW MTMYLFGNVK LQQGDAWNDP TLAITLAASG WVFVIFHAIP EIHCTLLPAL
   301  QENTPNYFDT SQPRMRETAF EEDVQLPRAY MENKAFSMDE HNAALRTAGF PNGSLGKRPS
   361  GSLGKRPSAP FRSNVYQPTE MAVVLNGGTI PTAPPSHTGR HLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRC5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 213 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 213 nTPM
basal ganglia: 201 nTPM
cerebral cortex: 172 nTPM
hippocampal formation: 167 nTPM
midbrain: 164 nTPM
amygdala: 155 nTPM

Single-cell type

oligodendrocytes: 389 nCPM
late spermatids: 326 nCPM
bergmann glia: 309 nCPM
early spermatids: 268 nCPM
astrocytes: 258 nCPM
oligodendrocyte progenitor cells: 138 nCPM

Immune cell

naive CD4 T-cell: 2.8 nTPM
intermediate monocyte: 0.7 nTPM
memory CD4 T-cell: 0.7 nTPM
total PBMC: 0.5 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 1,043 nTPM
basal ganglia: 949 nTPM
medulla oblongata: 868 nTPM
cerebellum: 829 nTPM
midbrain: 743 nTPM
thalamus: 719 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPRC5B.

Disease | AllUniProt

Conditions GPRC5B is implicated in, by any mechanism.

Megalencephalic leukoencephalopathy with subcortical cysts 3 (MLC3) MIM:620447

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 81 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Megalencephalic leukoencephalopathy with subcortical cysts 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.02
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRC5B as an antibody target. Whether an autoantibody or antibody against GPRC5B could matter depends on whether native GPRC5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRC5B is annotated at the cell surface, where native GPRC5B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRC5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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