GPR156

Protein identityUniProt · HPA

UniProt accession

Q8NFN8

Gene

GPR156

Ensembl

ENSG00000175697

Chromosome

3

Canonical length

814 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Plasma membrane

OverviewNCBI Gene

G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

814 residues, UniProt reviewed canonical sequence.

>Q8NFN8|GPR156
     1  MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG
    61  LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI
   121  QTRLSMLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALLMADVILL
   181  MTWVLTDPIQ CLQILSVSMT VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA
   241  YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
   301  TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH PRGEKSSMER
   361  LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA PPASSPNKDV QAVASVHTLA
   421  AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS SYAQSLEGPG KDSSFSPGKE EKISDSKDFS
   481  DHLDSGCSQK PWTEQSLGPE RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR
   541  VSSVIREKLQ EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
   601  RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT DSRVRRPSSR
   661  KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS GSGRAPSPAA PCLSKASPDL
   721  PEQWQLWPPV PSGCASLSSQ HSYFDTESSS SDEFFCRCHR PYCEICFQSS SDSSDSGTSD
   781  TDPEPTGGLA SWEKLWARSK PIVNFKDDLK PTLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR156 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

2.5 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR156.

Disease | AllUniProt

Conditions GPR156 is implicated in, by any mechanism.

• Deafness, autosomal recessive, 121 (DFNB121) MIM:620551

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hearing loss, autosomal recessive 121
• Hearing loss, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0

gnomAD missense Z

1.04

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• gamma-aminobutyric acid signaling pathway
• stereocilium bundle organization

Molecular functions

• G protein-coupled GABA receptor activity

Cellular components

• G protein-coupled receptor heterodimeric complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR family 3, GABA-B receptor
• GPCR family 3, C-terminal
• 7 transmembrane sweet-taste receptor of 3 GCPR
• GPR156, 7TM domain

KeywordsUniProt

• Cell membrane
• Coiled coil
• Deafness
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Non-syndromic deafness
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix