Seroatlas · Human Serome Atlas

GPRC5D

G-protein coupled receptor family C group 5 member D

Also known as: GPC5D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZD1
Gene: GPRC5D
Ensembl: ENSG00000111291
Chromosome: 12
Canonical length: 345 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9NZD1|GPRC5D
     1  MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL
    61  PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG
   121  CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL
   181  MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP
   241  VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRAR
   301  DSDGAEEDVA LTSYGTPIQP QTVDPTQECF IPQAKLSPQQ DAGGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRC5D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skin: 26 nTPM
lung: 4.7 nTPM
salivary gland: 3.3 nTPM
duodenum: 1.7 nTPM
stomach: 1.5 nTPM
testis: 1.4 nTPM

Single-cell type

epicardial cells: 100 nCPM
plasma cells: 38 nCPM
late spermatids: 26 nCPM
endometrial luminal cells: 24 nCPM
esophageal apical cells: 12 nCPM
urothelial cells: 10 nCPM

Immune cell

memory B-cell: 15 nTPM
naive B-cell: 4.9 nTPM
total PBMC: 1.3 nTPM
eosinophil: 0.9 nTPM
memory CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

choroid plexus: 2.6 nTPM
medulla oblongata: 1.9 nTPM
midbrain: 1.9 nTPM
pons: 1 nTPM
thalamus: 1 nTPM
white matter: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRC5D as an antibody target. Whether an autoantibody or antibody against GPRC5D could matter depends on whether native GPRC5D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRC5D is annotated at the cell surface, where native GPRC5D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRC5D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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