Seroatlas · Human Serome Atlas

GPRC5A

Retinoic acid-induced protein 3

Also known as: PEIG-1, RAI3, RAI3_HUMAN, RAIG1, TIG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFJ5
Gene: GPRC5A
Ensembl: ENSG00000013588
Chromosome: 12
Canonical length: 357 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q8NFJ5|GPRC5A
     1  MATTVPDGCR NGLKSKYYRL CDKAEAWGIV LETVATAGVV TSVAFMLTLP ILVCKVQDSN
    61  RRKMLPTQFL FLLGVLGIFG LTFAFIIGLD GSTGPTRFFL FGILFSICFS CLLAHAVSLT
   121  KLVRGRKPLS LLVILGLAVG FSLVQDVIAI EYIVLTMNRT NVNVFSELSA PRRNEDFVLL
   181  LTYVLFLMAL TFLMSSFTFC GSFTGWKRHG AHIYLTMLLS IAIWVAWITL LMLPDFDRRW
   241  DDTILSSALA ANGWVFLLAY VSPEFWLLTK QRNPMDYPVE DAFCKPQLVK KSYGVENRAY
   301  SQEEITQGFE ETGDTLYAPY STHFQLQNQP PQKEFSIPRA HAWPSPYKDY EVKKEGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRC5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 190 nTPM

Expression across tissuesHPA

Tissue

lung: 190 nTPM
urinary bladder: 122 nTPM
colon: 53 nTPM
thyroid gland: 52 nTPM
rectum: 46 nTPM
blood vessel: 35 nTPM

Single-cell type

alveolar cells type 1: 3,635 nCPM
transitional alveolar cells: 2,175 nCPM
urothelial cells: 2,165 nCPM
respiratory basal cells: 1,158 nCPM
ocular epithelial cells: 1,155 nCPM
respiratory secretory cells: 987 nCPM

Immune cell

basophil: 3.6 nTPM
neutrophil: 0.7 nTPM
eosinophil: 0.4 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

midbrain: 33 nTPM
cerebral cortex: 26 nTPM
medulla oblongata: 25 nTPM
choroid plexus: 25 nTPM
thalamus: 22 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.62
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPRC5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EGFR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRC5A as an antibody target. Whether an autoantibody or antibody against GPRC5A could matter depends on whether native GPRC5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRC5A is annotated at the cell surface, where native GPRC5A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPRC5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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