Integrator complex subunit 6
IPR051113
Definition
The Integrator subunit 6 family is involved in the transcription and 3'-box-dependent processing of small nuclear RNAs (snRNA), including U1, U2, U4, U5, and U7. Family members are components of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II's largest subunit. They may also play a role in recruiting cytoplasmic dynein to the nuclear envelope. Additionally, some members may have tumor suppressor functions, as their ectopic expression can suppress tumor cell growth.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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