Seroatlas · Human Serome Atlas

CT45A5

Cancer/testis antigen family 45 member A5

Also known as: CT45-5, CT45.5, CT455_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DMU8
Gene: CT45A5
Ensembl: ENSG00000228836
Chromosome: X
Canonical length: 189 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P0DMU8|CT45A5
     1  MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
    61  GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
   121  EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
   181  LKKKLKRMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CT45A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

testis: 4.8 nTPM
basal ganglia: 4.3 nTPM
hypothalamus: 1.5 nTPM
pituitary gland: 1.5 nTPM
retina: 1 nTPM
pancreas: 0.7 nTPM

Single-cell type

differentiating spermatogonia: 1.1 nCPM
early primary spermatocytes: 0.4 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0.2 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

basal ganglia: 9 nTPM
cerebellum: 8.6 nTPM
pons: 8.5 nTPM
cerebral cortex: 7.6 nTPM
hypothalamus: 7.5 nTPM
thalamus: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
gnomAD missense Z: -3.86

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of CT45A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUPT5H

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CT45A5 as an antibody target. Whether an autoantibody or antibody against CT45A5 could matter depends on whether native CT45A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CT45A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CT45A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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