Seroatlas · Human Serome Atlas

CT45A10

Cancer/testis antigen family 45 member A10

Also known as: CT45A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMU9
Gene
CT45A10
Ensembl
ENSG00000269586
Chromosome
X
Canonical length
189 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables identical protein binding activity. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P0DMU9|CT45A10
     1  MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
    61  GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS NFSGDDLECR GIASSPKSQQ
   121  EINADIKCQV VKEIRCLGRK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
   181  LKKKLKRMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CT45A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
8.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 8.7 nTPM
  • hippocampal formation: 0.7 nTPM
  • amygdala: 0.5 nTPM
  • spinal cord: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • midbrain: 0.4 nTPM

Single-cell type

  • differentiating spermatogonia: 62 nCPM
  • early primary spermatocytes: 33 nCPM
  • undifferentiated spermatogonia: 6.7 nCPM
  • late spermatids: 1.1 nCPM
  • sertoli cells: 1.1 nCPM
  • late primary spermatocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 3.2 nTPM
  • medulla oblongata: 2.3 nTPM
  • thalamus: 2 nTPM
  • hippocampal formation: 1.7 nTPM
  • white matter: 0.8 nTPM
  • amygdala: 0.6 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CT45A10 as an antibody target. Whether an autoantibody or antibody against CT45A10 could matter depends on whether native CT45A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CT45A10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CT45A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CT45A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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