CT45A7
Cancer/testis antigen family 45 member A7
Also known as: CT457_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DMV0
- Gene
- CT45A7
- Ensembl
- ENSG00000273696
- Chromosome
- X
- Canonical length
- 189 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
189 residues, UniProt reviewed canonical sequence.
>P0DMV0|CT45A7
1 MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
61 GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
121 EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
181 LKKKLKRMILocalizationUniProt · AlphaFold · HPA
Whether an antibody against CT45A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 0.2 nTPM
Expression across tissuesHPA
Tissue
- testis: 0.2 nTPM
- adipose tissue: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- lung: 0.1 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- b-cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CT45A7 as an antibody target. Whether an autoantibody or antibody against CT45A7 could matter depends on whether native CT45A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CT45A7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CT45A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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