Seroatlas · Human Serome Atlas

SAGE2P

Putative SAGE1-like protein

Also known as: SGE2P_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJ88
Gene: SAGE2P
Canonical length: 616 aa

OverviewNCBI Gene

No narrative summary is available for SAGE2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

616 residues, UniProt reviewed canonical sequence.

>A6NJ88|SAGE2P
     1  MYSQEDHIFQ LCSTDLCASY VPVINQSVLV THIVNYEDYL QIQASPLQTS QPTPPEELHT
    61  VGYVFTNDGQ QTRSDEVNQV ATGHQSKQKR SRESKRHSSS KRRKSMSRWL NKQEDAAVTH
   121  IVCEEKINND QPAPDNVLST APPWLRDMAA AGISSTSTRD LYATVTHNVC DERMENDQLQ
   181  LNNVLLTFPP ERVNMAVADF SAMSPRDLYA TINHNVYEVR MENNQPQFNN VLSTVKPGHI
   241  NMAAAGIPAM SAKDAVVNLN VHGEKINKGQ PAPDNFLSSV TPGLINVSGD GATVTHNAYE
   301  EKMENGQQAA DNILSAVPPG LINTSEAGIP AMSTNDLYAT ITHDVSEKKI KNSQPATDNF
   361  LCTVTPGLIN LAEAGILATS TRDLYDTATH NVHEEKMKNK HLITPCQQFH WDLLICQELL
   421  NFFIWIPDAT VIHNIQEEEM ENGQMPPDGF LSNSAPLELI NMTEDCMPLN ALDSFSYDFT
   481  SLSREELLYK HDSNEFAVGT KNYSVSAGDP PVTAMSSVET PQISPAMAKK INQDIKCQLM
   541  KEVQRFGQNY KRIFILLEEL QGSMKVKRQF VEFTIREAVR FKKVALIQQL EKVLKEIDSH
   601  CHLRKVKHMR KKIIVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAGE2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47

OntologyGO

Biological processes

snRNA 3'-end processing

Cellular components

integrator complex

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAGE2P as an antibody target. Whether an autoantibody or antibody against SAGE2P could matter depends on whether native SAGE2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAGE2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAGE2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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