Seroatlas · Human Serome Atlas

INTS6

Integrator complex subunit 6

Also known as: DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, INT6_HUMAN, Notchl2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL03
Gene: INTS6
Ensembl: ENSG00000102786
Chromosome: 13
Canonical length: 887 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

887 residues, UniProt reviewed canonical sequence.

>Q9UL03|INTS6
     1  MPILLFLIDT SASMNQRSHL GTTYLDTAKG AVETFMKLRA RDPASRGDRY MLVTFEEPPY
    61  AIKAGWKENH ATFMNELKNL QAEGLTTLGQ SLRTAFDLLN LNRLVTGIDN YGQGRNPFFL
   121  EPAIIITITD GSKLTTTSGV QDELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGTMS
   181  VESEQLTGVP LDDSAITPMC EVTGGRSYSV CSPRMLNQCL ESLVQKVQSG VVINFEKAGP
   241  DPSPVEDGQP DISRPFGSQP WHSCHKLIYV RPNPKTGVPI GHWPVPESFW PDQNSPTLPP
   301  RTSHPVVKFS CTDCEPMVID KLPFDKYELE PSPLTQFILE RKSPQTCWQV YVSNSAKYSE
   361  LGHPFGYLKA STALNCVNLF VMPYNYPVLL PLLDDLFKVH KAKPTLKWRQ SFESYLKTMP
   421  PYYLGPLKKA VRMMGAPNLI ADSMEYGLSY SVISYLKKLS QQAKIESDRV IGSVGKKVVQ
   481  ETGIKVRSRS HGLSMAYRKD FQQLLQGISE DVPHRLLDLN MKEYTGFQVA LLNKDLKPQT
   541  FRNAYDIPRR NLLDHLTRMR SNLLKSTRRF LKGQDEDQVH SVPIAQMGNY QEYLKQVPSP
   601  LRELDPDQPR RLHTFGNPFK LDKKGMMIDE ADEFVAGPQN KHKRPGEPNM QGIPKRRRCM
   661  SPLLRGRQQN PVVNNHIGGK GPPAPTTQAQ PDLIKPLPLH KISETTNDSI IHDVVENHVA
   721  DQLSSDITPN AMDTEFSASS PASLLERPTN HMEALGHDHL GTNDLTVGGF LENHEEPRDK
   781  EQCAEENIPA SSLNKGKKLM HCRSHEEVNT ELKAQIMKEI RKPGRKYERI FTLLKHVQGS
   841  LQTRLIFLQN VIKEASRFKK RMLIEQLENF LDEIHRRANQ INHINSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
pancreas: 36 nTPM
liver: 26 nTPM
lymph node: 19 nTPM
thymus: 19 nTPM
esophagus: 19 nTPM

Single-cell type

epididymal basal cells: 696 nCPM
breast myoepithelial cells: 599 nCPM
neutrophils: 451 nCPM
pdcs: 448 nCPM
breast secretory cells: 437 nCPM
neutrophil progenitors: 405 nCPM

Immune cell

basophil: 8.1 nTPM
MAIT T-cell: 6.7 nTPM
naive CD8 T-cell: 6.5 nTPM
gdT-cell: 5.9 nTPM
naive CD4 T-cell: 5.6 nTPM
neutrophil: 5.5 nTPM

Brain region

cerebellum: 58 nTPM
white matter: 57 nTPM
choroid plexus: 44 nTPM
medulla oblongata: 42 nTPM
pons: 41 nTPM
cerebral cortex: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INTS6.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 78
INTS6-associated neurodevelopmental disorder
INTS6-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 3.83
DepMap mean gene effect: -0.87
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS6 as an antibody target. Whether an autoantibody or antibody against INTS6 could matter depends on whether native INTS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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