Seroatlas · Human Serome Atlas

INTS6L

Integrator complex subunit 6-like

Also known as: DDX26B, FLJ41215, INT6L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JSJ4
Gene: INTS6L
Ensembl: ENSG00000165359
Chromosome: X
Canonical length: 861 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Centrosome,Mitochondria

OverviewNCBI Gene

Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

861 residues, UniProt reviewed canonical sequence.

>Q5JSJ4|INTS6L
     1  MPILLFLIDT SASMNQRTDL GTSYLDIAKG AVELFLKLRA RDPASRGDRY MLVTYDEPPY
    61  CIKAGWKENH ATFMSELKNL QASGLTTLGQ ALRSSFDLLN LNRLISGIDN YGQGRNPFFL
   121  EPSILITITD GNKLTSTAGV QEELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGVAS
   181  TEPEQLGSVP TDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVINFEKTGP
   241  DPLPIGEDGL MDSSRPSNSF AAQPWHSCHK LIYVRPNSKT GVPVGHWPIP ESFWPDQNLP
   301  SLPPRTSHPV VRFSCVDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHT CWQVFVTSSG
   361  KYNELGYPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL FKVHKLKPNL KWRQAFDSYL
   421  KTLPPYYLLT KLESERILAS VGKKPPQEIG IKVKNHSGGG MSLTHNKNFR KLLKEITGET
   481  ALRLTELNTK EFAGFQIGLL NKDLKPQTYR NAYDIPRRGL LDQLTRMRSN LLKTHKFIVG
   541  QDEDSLHSVP VAQMGNYQEY LKTLASPLRE IDPDQPKRLH TFGNPFKQDK KGMMIDEADE
   601  FVAGPQNKVK RPGEPNSPMS SKRRRSMSLL LRKPQTPPTV TNHVGGKGPP SASWFPSYPN
   661  LIKPTLVHTD ATIIHDGHEE KMENGQITPD GFLSKSAPSE LINMTGDLMP PNQVDSLSDD
   721  FTSLSKDGLI QKPGSNAFVG GAKNCSLSVD DQKDPVASTL GAMPNTLQIT PAMAQGINAD
   781  IKHQLMKEVR KFGRKYERIF ILLEEVQGPL EMKKQFVEFT IKEAARFKRR VLIQYLEKVL
   841  EKINSHHLHN NISHINSRSS C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS6L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
lymph node: 12 nTPM
salivary gland: 11 nTPM
tonsil: 11 nTPM
spleen: 9.7 nTPM
cerebellum: 8.4 nTPM

Single-cell type

sertoli cells: 239 nCPM
ependymal cells: 146 nCPM
mast cells: 137 nCPM
salivary myoepithelial cells: 126 nCPM
adrenal medulla cells: 117 nCPM
retinal horizontal cells: 108 nCPM

Immune cell

naive CD4 T-cell: 5.2 nTPM
MAIT T-cell: 3.8 nTPM
naive B-cell: 3.6 nTPM
memory CD8 T-cell: 3.5 nTPM
memory CD4 T-cell: 3.4 nTPM
naive CD8 T-cell: 3.4 nTPM

Brain region

cerebellum: 17 nTPM
midbrain: 6.6 nTPM
medulla oblongata: 6.5 nTPM
white matter: 6.5 nTPM
cerebral cortex: 6.1 nTPM
hypothalamus: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

snRNA 3'-end processing

Cellular components

integrator complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS6L as an antibody target. Whether an autoantibody or antibody against INTS6L could matter depends on whether native INTS6L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS6L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS6L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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