Seroatlas · Human Serome Atlas

ZC3H12C

Probable ribonuclease ZC3H12C

Also known as: KIAA1726, MCPIP3, ZC12C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0D7
Gene: ZC3H12C
Ensembl: ENSG00000149289
Chromosome: 11
Canonical length: 883 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Golgi apparatus

OverviewNCBI Gene

Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

883 residues, UniProt reviewed canonical sequence.

>Q9C0D7|ZC3H12C
     1  MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST DPQLSPAVPW
    61  STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES EQLGSISVEP GLITKTHRQL
   121  CRSPCLEPHI LKRNEILQDF KPEESQTTSK EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ
   181  LVLNKLGTDA LINDILGELV KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD
   241  DGENLRPIVI DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD
   301  ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII VSNDNYRDLA
   361  NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKKPIVPE HKKQPCPYGK
   421  KCTYGHKCKY YHPERGSQPQ RSVADELRAM SRNTAAKTAN EGGLVKSNSV PCSTKADSTS
   481  DVKRGAPKRQ SDPSIRTQVY QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN
   541  GLPSGVHFPP QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS
   601  LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS SPDPQLEENL
   661  KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK PPLPHLALHL PHSAVGARSS
   721  CPGDYPSPPS SAHSKAPHLG RSLVATRIDS ISDSRLYDSS PSRQRKPYSR QEGLGSWERP
   781  GYGIDAYGYR QTYSLPDNST QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK
   841  IYINLCNIFP PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H12C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

tongue: 12 nTPM
skeletal muscle: 9.9 nTPM
thyroid gland: 7.6 nTPM
skin: 5.5 nTPM
urinary bladder: 5 nTPM
ovary: 4.8 nTPM

Single-cell type

urothelial cells: 242 nCPM
melanocytes: 241 nCPM
hematopoietic stem cells: 215 nCPM
megakaryocyte progenitors: 180 nCPM
lactotrophs: 163 nCPM
adrenal cortex cells: 162 nCPM

Immune cell

basophil: 5.9 nTPM
classical monocyte: 0.1 nTPM
T-reg: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 25 nTPM
basal ganglia: 24 nTPM
cerebellum: 23 nTPM
white matter: 23 nTPM
midbrain: 22 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H12C as an antibody target. Whether an autoantibody or antibody against ZC3H12C could matter depends on whether native ZC3H12C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H12C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H12C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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