Seroatlas · Human Serome Atlas

ZC3H12B

Probable ribonuclease ZC3H12B

Also known as: CXorf32, MCPIP2, ZC12B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYM0
Gene: ZC3H12B
Ensembl: ENSG00000102053
Chromosome: X
Canonical length: 836 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q5HYM0|ZC3H12B
     1  MTATAEVETP KMEKSASKEE KQQPKQDSTE QGNADSEEWM SSESDPEQIS LKSSDNSKSC
    61  QPRDGQLKKK EMHSKPHRQL CRSPCLDRPS FSQSSILQDG KLDLEKEYQA KMEFALKLGY
   121  AEEQIQSVLN KLGPESLIND VLAELVRLGN KGDSEGQINL SLLVPRGPSS REIASPELSL
   181  EDEIDNSDNL RPVVIDGSNV AMSHGNKEEF SCRGIQLAVD WFLDKGHKDI TVFVPAWRKE
   241  QSRPDAPITD QDILRKLEKE KILVFTPSRR VQGRRVVCYD DRFIVKLAFD SDGIIVSNDN
   301  YRDLQVEKPE WKKFIEERLL MYSFVNDKFM PPDDPLGRHG PSLENFLRKR PIVPEHKKQP
   361  CPYGKKCTYG HKCKYYHPER ANQPQRSVAD ELRISAKLST VKTMSEGTLA KCGTGMSSAK
   421  GEITSEVKRV APKRQSDPSI RSVAMEPEEW LSIARKPEAS SVPSLVTALS VPTIPPPKSH
   481  AVGALNTRSA SSPVPGSSHF PHQKASLEHM ASMQYPPILV TNSHGTPISY AEQYPKFESM
   541  GDHGYYSMLG DFSKLNINSM HNREYYMAEV DRGVYARNPN LCSDSRVSHT RNDNYSSYNN
   601  VYLAVADTHP EGNLKLHRSA SQNRLQPFPH GYHEALTRVQ SYGPEDSKQG PHKQSVPHLA
   661  LHAQHPSTGT RSSCPADYPM PPNIHPGATP QPGRALVMTR MDSISDSRLY ESNPVRQRRP
   721  PLCREQHASW DPLPCTTDSY GYHSYPLSNS LMQPCYEPVM VRSVPEKMEQ LWRNPWVGMC
   781  NDSREHMIPE HQYQTYKNLC NIFPSNIVLA VMEKNPHTAD AQQLAALIVA KLRAAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 2.9 nTPM
basal ganglia: 2.6 nTPM
cerebellum: 2.3 nTPM
hippocampal formation: 2.2 nTPM
pituitary gland: 2.1 nTPM
retina: 2.1 nTPM

Single-cell type

somatotrophs: 713 nCPM
lactotrophs: 660 nCPM
thyrotrophs: 591 nCPM
fibro-adipogenic progenitors: 578 nCPM
corticotrophs: 509 nCPM
gonadotrophs: 456 nCPM

Immune cell

naive CD4 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

basal ganglia: 11 nTPM
cerebral cortex: 10 nTPM
white matter: 9.9 nTPM
hippocampal formation: 9.4 nTPM
hypothalamus: 8.8 nTPM
cerebellum: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H12B as an antibody target. Whether an autoantibody or antibody against ZC3H12B could matter depends on whether native ZC3H12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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