Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
IPR050776
Definition
The protein family includes ankyrin repeat domain-containing proteins and cyclin-dependent kinase inhibitors. Ankyrin repeat proteins may play roles in cell division and other regulatory functions, while cyclin-dependent kinase inhibitors are involved in cell cycle regulation by interacting with CDK4 and CDK6, inhibiting cell growth and proliferation. Some family members are involved in endosomal mRNA transport, chitinase secretion, and phosphoprotein substrate recognition. Others may act as substrate-recognition components of E3 ubiquitin-protein ligase complexes, mediating ubiquitination and proteasomal degradation of target proteins.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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