Seroatlas · Human Serome Atlas

ANKRD42

Ankyrin repeat domain-containing protein 42

Also known as: ANR42_HUMAN, FLJ37874, PPP1R79, SARP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9B4
Gene: ANKRD42
Ensembl: ENSG00000137494
Chromosome: 11
Canonical length: 389 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable NF-kappaB binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity and positive regulation of cytokine production involved in inflammatory response. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q8N9B4|ANKRD42
     1  MPGVANSGPS TSSRETANPC SRKKVHFGSI HDAVRAGDVK QLSEIVCLHW LLWHGADITH
    61  VTTRGWTASH IAAIRGQDAC VQALIMNGAN LTAQDDRGCT PLHLAATHGH SFTLQIMLRS
   121  GVDPSVTDKR EWRPVHYAAF HGRLGCLQLL VKWGCSIEDV DYNGNLPVHL AAMEGHLHCF
   181  KFLVSRMSSA TQVLKAFNDN GENVLDLAQR FFKQNILQFI QGAEYEGKDL EDQETLAFPG
   241  HVAAFKGDLG MLKKLVEDGV ININERADNG STPMHKAAGQ GHIECLQWLI KMGADSNITN
   301  KAGERPSDVA KRFAHLAAVK LLEELQKYDI DDENEIDEND VKYFIRHGVE GSTDAKDDLC
   361  LSDLDKTDAR RPSKNCRASW SMNDYVEKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
choroid plexus: 20 nTPM
epididymis: 19 nTPM
retina: 17 nTPM
fallopian tube: 15 nTPM
adrenal gland: 12 nTPM

Single-cell type

early spermatids: 165 nCPM
late primary spermatocytes: 159 nCPM
endometrial ciliated cells: 117 nCPM
fallopian tube ciliated cells: 108 nCPM
respiratory ciliated cells: 107 nCPM
ependymal cells: 96 nCPM

Immune cell

non-classical monocyte: 8.1 nTPM
basophil: 5.7 nTPM
memory B-cell: 5 nTPM
NK-cell: 4.4 nTPM
naive B-cell: 3.8 nTPM
myeloid DC: 3.5 nTPM

Brain region

choroid plexus: 43 nTPM
hypothalamus: 39 nTPM
cerebral cortex: 33 nTPM
hippocampal formation: 33 nTPM
medulla oblongata: 31 nTPM
midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD42 as an antibody target. Whether an autoantibody or antibody against ANKRD42 could matter depends on whether native ANKRD42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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