Seroatlas · Human Serome Atlas

ANKRD10

Ankyrin repeat domain-containing protein 10

Also known as: ANR10_HUMAN, FLJ20093

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXR5
Gene: ANKRD10
Ensembl: ENSG00000088448
Chromosome: 13
Canonical length: 420 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in protein targeting to chloroplast. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q9NXR5|ANKRD10
     1  MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL ASEDSFYGWT
    61  PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA FGGHPQCLVW LIQAGANINK
   121  PDCEGETPIH KAARSGSLEC ISALVANGAH VDLRNASGLT AADIAQTQGF QECAQFLLNL
   181  QNCHLNHFYN NGILNGGHQN VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL
   241  TNGDTEDDAD KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG
   301  QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL NGSPSSCIAS
   361  RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV KVQERYDSAV LGTMHLHHGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 167 nTPM
spleen: 133 nTPM
prostate: 103 nTPM
cervix: 98 nTPM
ovary: 96 nTPM
pituitary gland: 94 nTPM

Single-cell type

myonuclei: 383 nCPM
myosatellite cells: 365 nCPM
cardiomyocytes: 260 nCPM
renal connecting tubule cells: 235 nCPM
distal convoluted tubule cells: 228 nCPM
adipocytes: 218 nCPM

Immune cell

naive B-cell: 45 nTPM
memory B-cell: 43 nTPM
T-reg: 40 nTPM
basophil: 39 nTPM
myeloid DC: 34 nTPM
naive CD8 T-cell: 34 nTPM

Brain region

white matter: 95 nTPM
medulla oblongata: 88 nTPM
choroid plexus: 80 nTPM
pons: 75 nTPM
basal ganglia: 74 nTPM
hypothalamus: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.16
gnomAD missense Z: 1.35
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD10 as an antibody target. Whether an autoantibody or antibody against ANKRD10 could matter depends on whether native ANKRD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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