ANKRD37
Ankyrin repeat domain-containing protein 37
Also known as: ANR37_HUMAN, Lrp2bp
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z713
- Gene
- ANKRD37
- Ensembl
- ENSG00000186352
- Chromosome
- 4
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q7Z713|ANKRD37
1 MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ LQTGADLNQQ
61 DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA EDLAWSCGFP DCAKFLTTIK
121 CMQTIKASEH PDRNDCVAVL RQKRSLGSVE NTSGKRKCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANKRD37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 114 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 114 nTPM
- choroid plexus: 96 nTPM
- esophagus: 95 nTPM
- retina: 87 nTPM
- vagina: 51 nTPM
- heart muscle: 44 nTPM
Single-cell type
- esophageal apical cells: 4,835 nCPM
- pancreatic acinar cells: 1,236 nCPM
- conjunctival goblet cells: 324 nCPM
- goblet cells: 310 nCPM
- breast lactating cells: 310 nCPM
- esophageal suprabasal cells: 305 nCPM
Immune cell
- eosinophil: 8.4 nTPM
- naive B-cell: 6.9 nTPM
- memory B-cell: 6.8 nTPM
- memory CD8 T-cell: 6.7 nTPM
- T-reg: 4.5 nTPM
- gdT-cell: 4.1 nTPM
Brain region
- choroid plexus: 40 nTPM
- thalamus: 18 nTPM
- medulla oblongata: 17 nTPM
- spinal cord: 17 nTPM
- midbrain: 15 nTPM
- cerebral cortex: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.34
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANKRD37 as an antibody target. Whether an autoantibody or antibody against ANKRD37 could matter depends on whether native ANKRD37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANKRD37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANKRD37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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