Seroatlas · Human Serome Atlas

ANKRD45

Ankyrin repeat domain-containing protein 45

Also known as: ANR45_HUMAN, CT117, FLJ45235

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TZF3
Gene: ANKRD45
Ensembl: ENSG00000183831
Chromosome: 1
Canonical length: 266 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Involved in cell population proliferation. Located in several cellular components, including centrosome; cleavage furrow; and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q5TZF3|ANKRD45
     1  MESEGPPESE SSEFFSQQEE ENEEEEAQEP EETGPKNPLL QPALTGDVEG LQKIFEDPEN
    61  PHHEQAMQLL LEEDIVGRNL LYAACMAGQS DVIRALAKYG VNLNEKTTRG YTLLHCAAAW
   121  GRLETLKALV ELDVDIEALN FREERARDVA ARYSQTECVE FLDWADARLT LKKYIAKVSL
   181  AVTDTEKGSG KLLKEDKNTI LSACRAKNEW LETHTEASIN ELFEQRQQLE DIVTPIFTKM
   241  TTPCQVKSAK SVTSHDQKRS QDDTSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 12 nTPM
parathyroid gland: 8.7 nTPM
choroid plexus: 6 nTPM
testis: 5 nTPM
basal ganglia: 3.2 nTPM
cerebral cortex: 2.6 nTPM

Single-cell type

renal collecting duct principal cells: 13 nCPM
renal connecting tubule cells: 9.2 nCPM
loop of henle epithelial cells: 4.8 nCPM
podocytes: 4.6 nCPM
proximal tubule cells: 3.2 nCPM
distal convoluted tubule cells: 2.4 nCPM

Immune cell

basophil: 0.2 nTPM
total PBMC: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 34 nTPM
midbrain: 18 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 14 nTPM
hippocampal formation: 12 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell population proliferation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD45 as an antibody target. Whether an autoantibody or antibody against ANKRD45 could matter depends on whether native ANKRD45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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