Cell Cycle and Stress Response Kinase
IPR050339
Definition
The protein family includes serine/threonine and tyrosine kinases that play crucial roles in cell cycle regulation, stress response, and translation initiation. Members of the family negatively regulate the transition from G2 to M phase in mitosis by phosphorylating CDK1, thus preventing premature mitotic entry. They are also involved in meiotic arrest and exit during oocyte maturation. Additionally, some family members sense metabolic stress and activate the integrated stress response by phosphorylating EIF2S1/eIF-2-alpha, leading to global protein synthesis inhibition and preferential translation of stress response mRNAs. This response is crucial for cellular adaptation to conditions such as amino acid starvation, unfolded protein response, and heme deficiency. The family also includes kinases that regulate the immune response to viral infection by phosphorylating EIF2S1/eIF-2-alpha, contributing to antiviral defense mechanisms.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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