WEE2

Protein identityUniProt · HPA

UniProt accession

P0C1S8

Gene

WEE2

Ensembl

ENSG00000214102

Chromosome

7

Canonical length

567 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of meiotic cell cycle. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>P0C1S8|WEE2
     1  MDDKDIDKEL RQKLNFSYCE ETEIEGQKKV EESREASSQT PEKGEVQDSE AKGTPPWTPL
    61  SNVHELDTSS EKDKESPDQI LRTPVSHPLK CPETPAQPDS RSKLLPSDSP STPKTMLSRL
   121  VISPTGKLPS RGPKHLKLTP APLKDEMTSL ALVNINPFTP ESYKKLFLQS GGKRKIRGDL
   181  EEAGPEEGKG GLPAKRCVLR ETNMASRYEK EFLEVEKIGV GEFGTVYKCI KRLDGCVYAI
   241  KRSMKTFTEL SNENSALHEV YAHAVLGHHP HVVRYYSSWA EDDHMIIQNE YCNGGSLQAA
   301  ISENTKSGNH FEEPKLKDIL LQISLGLNYI HNSSMVHLDI KPSNIFICHK MQSESSGVIE
   361  EVENEADWFL SANVMYKIGD LGHATSINKP KVEEGDSRFL ANEILQEDYR HLPKADIFAL
   421  GLTIAVAAGA ESLPTNGAAW HHIRKGNFPD VPQELSESFS SLLKNMIQPD AEQRPSAAAL
   481  ARNTVLRPSL GKTEELQQQL NLEKFKTATL ERELREAQQA QSPQGYTHHG DTGVSGTHTG
   541  SRSTKRLVGG KSARSSSFTS GEREPLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WEE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

0.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WEE2.

Disease | AllUniProt

Conditions WEE2 is implicated in, by any mechanism.

• Oocyte/zygote/embryo maturation arrest 5 (OZEMA5) MIM:617996

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 110 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Oocyte maturation defect 5
• WEE2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0

gnomAD missense Z

0.58

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• female meiotic nuclear division
• mitotic cell cycle
• negative regulation of oocyte maturation
• positive regulation of phosphorylation
• regulation of fertilization
• regulation of meiosis I
• female pronucleus assembly

Molecular functions

• ATP binding
• magnesium ion binding
• non-membrane spanning protein tyrosine kinase activity
• protein tyrosine kinase activity

Cellular components

• cytoplasm
• cytosol
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Wee1-like protein kinase
• Protein kinase, ATP binding site
• Cell Cycle and Stress Response Kinase
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Coiled coil
• Kinase
• Magnesium
• Meiosis
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Transferase
• Tyrosine-protein kinase