Seroatlas · Human Serome Atlas

PDIK1L

Serine/threonine-protein kinase PDIK1L

Also known as: CLIK1L, PDK1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N165
Gene: PDIK1L
Ensembl: ENSG00000175087
Chromosome: 1
Canonical length: 341 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of G2/MI transition of meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8N165|PDIK1L
     1  MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA LREFWALSSI
    61  KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS LKGEIAFDPR SAYYLWFVMD
   121  FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS ALAFLHKNQI IHRDLKPDNI LISQTRLDTS
   181  DLEPTLKVAD FGLSKVCSAS GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI
   241  FALGIIIWAM LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
   301  NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDIK1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
thyroid gland: 14 nTPM
thymus: 8 nTPM
breast: 7.7 nTPM
liver: 7.6 nTPM
retina: 7.6 nTPM

Single-cell type

myonuclei: 55 nCPM
early primary spermatocytes: 40 nCPM
neutrophil progenitors: 40 nCPM
parietal cells: 39 nCPM
erythrocyte progenitors: 36 nCPM
plasma cells: 30 nCPM

Immune cell

basophil: 11 nTPM
T-reg: 8 nTPM
myeloid DC: 7.4 nTPM
naive CD4 T-cell: 7 nTPM
memory CD4 T-cell: 6.6 nTPM
naive CD8 T-cell: 5.6 nTPM

Brain region

cerebellum: 17 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
pons: 14 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.26
gnomAD missense Z: 3.27
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDIK1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDIK1L as an antibody target. Whether an autoantibody or antibody against PDIK1L could matter depends on whether native PDIK1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDIK1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDIK1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...