Seroatlas · Human Serome Atlas

STK35

Serine/threonine-protein kinase 35

Also known as: bA550O8.2, CLIK1, STK35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDR2
Gene: STK35
Ensembl: ENSG00000125834
Chromosome: 20
Canonical length: 534 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q8TDR2|STK35
     1  MGHQESPLAR APAGGAAYVK RLCKGLSWRE HVESHGSLGA QASPASAAAA EGSATRRARA
    61  ATSRAARSRR QPGPGADHPQ AGAPGGKRAA RKWRCAGQVT IQGPAPPRPR AGRRDEAGGA
   121  RAAPLLLPPP PAAMETGKDG ARRGTQSPER KRRSPVPRAP STKLRPAAAA RAMDPVAAEA
   181  PGEAFLARRR PEGGGGSARP RYSLLAEIGR GSYGVVYEAV AGRSGARVAV KKIRCDAPEN
   241  VELALAEFWA LTSLKRRHQN VVQFEECVLQ RNGLAQRMSH GNKSSQLYLR LVETSLKGER
   301  ILGYAEEPCY LWFVMEFCEG GDLNQYVLSR RPDPATNKSF MLQLTSAIAF LHKNHIVHRD
   361  LKPDNILITE RSGTPILKVA DFGLSKVCAG LAPRGKEGNQ DNKNVNVNKY WLSSACGSDF
   421  YMAPEVWEGH YTAKADIFAL GIIIWAMIER ITFIDSETKK ELLGTYIKQG TEIVPVGEAL
   481  LENPKMELHI PQKRRTSMSE GIKQLLKDML AANPQDRPDA FELETRMDQV TCAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

retina: 110 nTPM
testis: 17 nTPM
esophagus: 16 nTPM
adrenal gland: 11 nTPM
skin: 11 nTPM
cerebellum: 10 nTPM

Single-cell type

late spermatids: 1,511 nCPM
müller glia: 693 nCPM
retinal horizontal cells: 371 nCPM
cone photoreceptor cells: 358 nCPM
early spermatids: 269 nCPM
rod photoreceptor cells: 249 nCPM

Immune cell

neutrophil: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
memory CD4 T-cell: 0.6 nTPM
myeloid DC: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM

Brain region

thalamus: 38 nTPM
cerebral cortex: 33 nTPM
midbrain: 29 nTPM
amygdala: 26 nTPM
hippocampal formation: 26 nTPM
hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.48
gnomAD missense Z: 2.3
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK35 as an antibody target. Whether an autoantibody or antibody against STK35 could matter depends on whether native STK35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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