Seroatlas · Human Serome Atlas

RXRB

Retinoic acid receptor RXR-beta

Also known as: H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRB_HUMAN, RXRbeta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28702
Gene
RXRB
Ensembl
ENSG00000204231
Chromosome
6
Canonical length
533 aa
Protein class
Cancer-related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>P28702|RXRB
     1  MSWAARPPFL PQRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA AAVAGGEQQT
    61  PEPEPGEAGR DGMGDSGRDS RSPDSSSPNP LPQGVPPPSP PGPPLPPSTA PSLGGSGAPP
   121  PPPMPPPPLG SPFPVISSSM GSPGLPPPAP PGFSGPVSSP QINSTVSLPG GGSGPPEDVK
   181  PPVLGVRGLH CPPPPGGPGA GKRLCAICGD RSSGKHYGVY SCEGCKGFFK RTIRKDLTYS
   241  CRDNKDCTVD KRQRNRCQYC RYQKCLATGM KREAVQEERQ RGKDKDGDGE GAGGAPEEMP
   301  VDRILEAELA VEQKSDQGVE GPGGTGGSGS SPNDPVTNIC QAADKQLFTL VEWAKRIPHF
   361  SSLPLDDQVI LLRAGWNELL IASFSHRSID VRDGILLATG LHVHRNSAHS AGVGAIFDRV
   421  LTELVSKMRD MRMDKTELGC LRAIILFNPD AKGLSNPSEV EVLREKVYAS LETYCKQKYP
   481  EQQGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLEAPH QLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RXRB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 43 nTPM
  • skeletal muscle: 41 nTPM
  • spleen: 37 nTPM
  • thyroid gland: 36 nTPM
  • cerebral cortex: 35 nTPM
  • blood vessel: 34 nTPM

Single-cell type

  • oligodendrocytes: 20 nCPM
  • bergmann glia: 19 nCPM
  • brain excitatory neurons: 18 nCPM
  • brain inhibitory neurons: 17 nCPM
  • oligodendrocyte progenitor cells: 17 nCPM
  • astrocytes: 17 nCPM

Immune cell

  • basophil: 2.3 nTPM
  • eosinophil: 1.7 nTPM
  • memory CD4 T-cell: 1.3 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • gdT-cell: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM

Brain region

  • hypothalamus: 4.1 nTPM
  • midbrain: 1.4 nTPM
  • spinal cord: 1.4 nTPM
  • cerebral cortex: 1.3 nTPM
  • thalamus: 1.3 nTPM
  • white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
3.42
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RXRB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RXRB as an antibody target. Whether an autoantibody or antibody against RXRB could matter depends on whether native RXRB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RXRB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RXRB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RXRB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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