NR2E1

Protein identityUniProt · HPA

UniProt accession

Q9Y466

Gene

NR2E1

Ensembl

ENSG00000112333

Chromosome

6

Canonical length

385 aa

Protein class

Nuclear receptors, Predicted intracellular proteins, Transcription factors

Subcellular location

Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q9Y466|NR2E1
     1  MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY VCKSGNQGGC
    61  PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR KQVALYFRGH KEENGAAAHF
   121  PSAALPAPAF FTAVTQLEPH GLELAAVSTT PERQTLVSLA QPTPKYPHEV NGTPMYLYEV
   181  ATESVCESAA RLLFMSIKWA KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN
   241  TLLAVSGMNG DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH
   301  SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL RSISPSTIEE
   361  VFFKKTIGNV PITRLLSDMY KSSDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR2E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.16

gnomAD pLI

1

gnomAD missense Z

2.6

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aggressive behavior
• amygdala development
• angiogenesis
• anterior commissure morphogenesis
• apoptotic process
• astrocyte cell migration
• astrocyte differentiation
• behavioral fear response
• cell differentiation
• cell fate commitment
• cerebral cortex neuron differentiation
• dentate gyrus development
• extracellular matrix organization
• layer formation in cerebral cortex
• long-term synaptic potentiation
• negative regulation of apoptotic process
• negative regulation of astrocyte differentiation
• negative regulation of neural precursor cell proliferation
• negative regulation of neuron differentiation
• negative regulation of transcription by RNA polymerase II
• nervous system development
• neuroblast proliferation
• olfactory bulb development
• positive regulation of angiogenesis
• positive regulation of cell cycle
• positive regulation of neuroblast proliferation
• positive regulation of stem cell proliferation
• regulation of cell migration involved in sprouting angiogenesis
• regulation of dendrite morphogenesis
• regulation of timing of neuron differentiation
• retina development in camera-type eye
• social behavior
• somatic stem cell population maintenance
• visual perception

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• histone deacetylase binding
• nuclear receptor activity
• nuclear steroid receptor activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Nuclear hormone receptor, ligand-binding domain
• Zinc finger, nuclear hormone receptor-type
• Nuclear hormone receptor
• Zinc finger, NHR/GATA-type
• Nuclear hormone receptor-like domain superfamily
• Nuclear hormone receptor family NR2 subfamily
• Ligand-binding domain of nuclear hormone receptor
• Double treble clef zinc finger, C4 type

KeywordsUniProt

• Activator
• Developmental protein
• DNA-binding
• Metal-binding
• Nucleus
• Receptor
• Repressor
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of NR2E1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATN1
• KDM1A