Seroatlas · Human Serome Atlas

RXRG

Retinoic acid receptor RXR-gamma

Also known as: NR2B3, RXR-gamma, RXRG_HUMAN, RXRgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48443
Gene
RXRG
Ensembl
ENSG00000143171
Chromosome
1
Canonical length
463 aa
Protein class
Cancer-related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>P48443|RXRG
     1  MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG
    61  TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG
   121  IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD
   181  CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL
   241  EAELAVEPKT ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
   301  LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD
   361  MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL
   421  LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLETPL QIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RXRG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 47 nTPM
  • pituitary gland: 30 nTPM
  • retina: 23 nTPM
  • basal ganglia: 20 nTPM
  • spinal cord: 16 nTPM
  • hypothalamus: 14 nTPM

Single-cell type

  • somatotrophs: 143 nCPM
  • cone photoreceptor cells: 135 nCPM
  • myosatellite cells: 60 nCPM
  • retinal ganglion cells: 54 nCPM
  • thyrotrophs: 41 nCPM
  • schwann cells: 38 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 50 nTPM
  • medulla oblongata: 38 nTPM
  • pons: 30 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 17 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RXRG.

Disease | ImmuneIEDB

Conditions an epitope on RXRG was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.42
gnomAD missense Z
1.59
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RXRG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RXRG as an antibody target. Whether an autoantibody or antibody against RXRG could matter depends on whether native RXRG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RXRG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RXRG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RXRG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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