Seroatlas · Human Serome Atlas

HNF4G

Hepatocyte nuclear factor 4-gamma

Also known as: HNF4G_HUMAN, NR2A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14541
Gene: HNF4G
Ensembl: ENSG00000164749
Chromosome: 8
Canonical length: 408 aa
Protein class: Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q14541|HNF4G
     1  MNTTDNGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK
    61  RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTFDGSN IPSINTLAQA EVRSRQISVS
   121  SPGSSTDINV KKIASIGDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL
   181  LLGATKRSMM YKDILLLGNN YVIHRNSCEV EISRVANRVL DELVRPFQEI QIDDNEYACL
   241  KAIVFFDPDA KGLSDPVKIK NMRFQVQIGL EDYINDRQYD SRGRFGELLL LLPTLQSITW
   301  QMIEQIQFVK LFGMVKIDNL LQEMLLGGAS NDGSHLHHPM HPHLSQDPLT GQTILLGPMS
   361  TLVHADQIST PETPLPSPPQ GSGQEQYKIA ANQASVISHQ HLSKQKQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNF4G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

small intestine: 108 nTPM
duodenum: 95 nTPM
colon: 19 nTPM
rectum: 18 nTPM
kidney: 16 nTPM
liver: 12 nTPM

Single-cell type

enterocytes: 772 nCPM
paneth cells: 375 nCPM
goblet cells: 291 nCPM
colonocytes: 273 nCPM
enteric transient amplifying cells: 265 nCPM
enteric stem cells: 253 nCPM

Immune cell

gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.7 nTPM
basal ganglia: 1.5 nTPM
medulla oblongata: 1.5 nTPM
spinal cord: 1.5 nTPM
hypothalamus: 1.3 nTPM
thalamus: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.07
gnomAD missense Z: 0.6
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNF4G as an antibody target. Whether an autoantibody or antibody against HNF4G could matter depends on whether native HNF4G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNF4G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNF4G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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