Seroatlas · Human Serome Atlas

COL20A1

Collagen alpha-1(XX) chain

Also known as: COKA1_HUMAN, KIAA1510

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P218
Gene
COL20A1
Ensembl
ENSG00000101203
Chromosome
20
Canonical length
1284 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

Predicted to be located in collagen-containing extracellular matrix; endoplasmic reticulum lumen; and extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1284 residues, UniProt reviewed canonical sequence.

>Q9P218|COL20A1
     1  MSSGDPAHLG LCLWLWLGAT LGREQVQASG LLRLAVLPED RLQMKWRESE GSGLGYLVQV
    61  KPMAGDSEQE VILTTKTPKA TVGGLSPSKG YTLQIFELTG SGRFLLARRE FVIEDLKSSS
   121  LDRSSQRPLG SGAPEPTPSH TGSPDPEQAS EPQVAFTPSQ DPRTPAGPQF RCLPPVPADM
   181  VFLVDGSWSI GHSHFQQVKD FLASVIAPFE IGPDKVQVGL TQYSGDAQTE WDLNSLSTKE
   241  QVLAAVRRLR YKGGNTFTGL ALTHVLGQNL QPAAGLRPEA AKVVILVTDG KSQDDVHTAA
   301  RVLKDLGVNV FAVGVKNADE AELRLLASPP RDITVHSVLD FLQLGALAGL LSRLICQRLQ
   361  GGSPRQGPAA APALDTLPAP TSLVLSQVTS SSIRLSWTPA PRHPLKYLIV WRASRGGTPR
   421  EVVVEGPAAS TELHNLASRT EYLVSVFPIY EGGVGEGLRG LVTTAPLPPP RALTLAAVTP
   481  RTVHLTWQPS AGATHYLVRC SPASPKGEEE EREVQVGRPE VLLDGLEPGR DYEVSVQSLR
   541  GPEGSEARGI RARTPTLAPP RHLGFSDVSH DAARVFWEGA PRPVRLVRVT YVSSEGGHSG
   601  QTEAPGNATS ATLGPLSSST TYTVRVTCLY PGGGSSTLTG RVTTKKAPSP SQLSMTELPG
   661  DAVQLAWVAA APSGVLVYQI TWTPLGEGKA HEISVPGNLG TAVLPGLGRH TEYDVTILAY
   721  YRDGARSDPV SLRYTPSTVS RSPPSNLALA SETPDSLQVS WTPPLGRVLH YWLTYAPASG
   781  LGPEKSVSVP GARSHVTLPD LQAATKYRVL VSAIYAAGRS EAVSATGQTA CPALRPDGSL
   841  PGFDLMVAFS LVEKAYASIR GVAMEPSAFG GTPTFTLFKD AQLTRRVSDV YPAPLPPEHT
   901  IVFLVRLLPE TPREAFALWQ MTAEDFQPLL GVLLDAGKKS LTYFHRDPRA ALQEATFDPQ
   961  EVRKIFFGSF HKVHVAVGRS KVRLYVDCRK VAERPLGEMG SPPAAGFVTL GRLAKARGPR
  1021  SSSAAFQLQM LQIVCSDTWA DEDRCCELPA SRDGETCPAF VSACSCSSET PGPPGPQGPP
  1081  GLPGRNGTPG EQGFPGPRGP PGVKGEKGDH GLPGLQGHPG HQGIPGRVGL QGPKGMRGLE
  1141  GTAGLPGPPG PRGFQGMAGA RGTSGERGPP GTVGPTGLPG PKGERGEKGE PQSLATLYQL
  1201  VSQASHVSKF DSFHENTRPP MPILEQKLEP GTEPLGSPGT RSKALVPGEW GRGGRHLEGR
  1261  GEPGAVGQMG SPGQQGASTQ GLWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COL20A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
7.2 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 7.2 nTPM
  • amygdala: 6.5 nTPM
  • hippocampal formation: 4.9 nTPM
  • midbrain: 4.5 nTPM
  • spinal cord: 4 nTPM
  • basal ganglia: 3.6 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 107 nCPM
  • retinal pigment epithelial cells: 94 nCPM
  • early primary spermatocytes: 21 nCPM
  • late primary spermatocytes: 16 nCPM
  • retinal horizontal cells: 16 nCPM
  • undifferentiated spermatogonia: 10 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 3.8 nTPM
  • white matter: 3.8 nTPM
  • thalamus: 2.8 nTPM
  • amygdala: 2.7 nTPM
  • basal ganglia: 2.6 nTPM
  • hippocampal formation: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
-0.45
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COL20A1 as an antibody target. Whether an autoantibody or antibody against COL20A1 could matter depends on whether native COL20A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COL20A1 is annotated as secreted, so native COL20A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COL20A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COL20A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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