Seroatlas · Human Serome Atlas

COL24A1

Collagen alpha-1(XXIV) chain

Also known as: COOA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RW2
Gene: COL24A1
Ensembl: ENSG00000171502
Chromosome: 1
Canonical length: 1714 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene is a member of the collagen gene family and is thought to regulate type I collagen fibrillogenesis during fetal development. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

1714 residues, UniProt reviewed canonical sequence.

>Q17RW2|COL24A1
     1  MHLRAHRTRR GKVSPTAKTK SLLHFIVLCV AGVVVHAQEQ GIDILHQLGL GGKDVRHSSP
    61  ATAVPSASTP LPQGVHLTES GVIFKNDAYI ETPFVKILPV NLGQPFTILT GLQSHRVNNA
   121  FLFSIRNKNR LQLGVQLLPK KLVVHIRGKQ PAVFNYSVHD EQWHSFAITI RNQSVSMFVE
   181  CGKKYFSTET IPEVQTFDSN SVFTLGSMNN NSIHFEGIVC QLDIIPSAEA SADYCRYVKQ
   241  QCRQADKYQP ETSIPCTTLI PTKIPEHSPP PKLFAEKVLS EDTFTEGKSI PNIIKNDSET
   301  VYKRQEHQIS RSQLSSLQSG NVSAVDLTNH GIQAKEMITE EDTQTNFSLS VTTHRISEAK
   361  MNTKEKFSSL LNMSDNITQH DDRVTGLSLF KKMPSILPQI KQDTITNLKK AITANLHTNE
   421  LMEMQPILNT SLHRVTNEPS VDNHLDLRKE GEFYPDATYP IENSYETELY DYYYYEDLNT
   481  MLEMEYLRGP KGDTGPPGPP GPAGIPGPSG KRGPRGIPGP HGNPGLPGLP GPKGPKGDPG
   541  FSPGQPVPGE KGDQGLSGLM GPPGMQGDKG LKGHPGLPGL PGEQGIPGFA GNIGSPGYPG
   601  RQGLAGPEGN PGPKGAQGFI GSPGEAGQLG PEGERGIPGI RGKKGFKGRQ GFPGDFGDRG
   661  PAGLDGSPGL VGGTGPPGFP GLRGSVGPVG PIGPAGIPGP MGLSGNKGLP GIKGDKGEQG
   721  TAGELGEPGY PGDKGAVGLP GPPGMRGKSG PSGQTGDPGL QGPSGPPGPE GFPGDIGIPG
   781  QNGPEGPKGL LGNRGPPGPP GLKGTQGEEG PIGAFGELGP RGKPGQKGYA GEPGPEGLKG
   841  EVGDQGNIGK IGETGPVGLP GEVGMTGSIG EKGERGSPGP LGPQGEKGVM GYPGPPGVPG
   901  PIGPLGLPGH VGARGPPGSQ GPKGQRGSRG PDGLLGEQGI QGAKGEKGDQ GKRGPHGLIG
   961  KTGNPGERGF QGKPGLQGLP GSTGDRGLPG EPGLRGLQGD VGPPGEMGME GPPGTEGESG
  1021  LQGEPGAKGD VGTAGSVGGT GEPGLRGEPG APGEEGLQGK DGLKGVPGGR GLPGEDGEKG
  1081  EMGLPGIIGP LGRSGQTGLP GPEGIVGIPG QRGRPGKKGD KGQIGPTGEV GSRGPPGKIG
  1141  KSGPKGARGT RGAVGHLGLM GPDGEPGIPG YRGHQGQPGP SGLPGPKGEK GYPGEDSTVL
  1201  GPPGPRGEPG PVGDQGERGE PGAEGYKGHV GVPGLRGATG QQGPPGEPGD QGEQGLKGER
  1261  GSEGNKGKKG APGPSGKPGI PGLQGLLGPK GIQGYHGADG ISGNPGKIGP PGKQGLPGIR
  1321  GGPGRTGLAG APGPPGVKGS SGLPGSPGIQ GPKGEQGLPG QPGIQGKRGH RGAQGDQGPC
  1381  GDPGLKGQPG EYGVQGLTGF QGFPGPKGPE GDAGIVGISG PKGPIGHRGN TGPLGREGII
  1441  GPTGRTGPRG EKGFRGETGP QGPRGQPGPP GPPGAPGPRK QMDINAAIQA LIESNTALQM
  1501  ESYQNTEVTL IDHSEEIFKT LNYLSNLLHS IKNPLGTRDN PARICKDLLN CEQKVSDGKY
  1561  WIDPNLGCPS DAIEVFCNFS AGGQTCLPPV SVTKLEFGVG KVQMNFLHLL SSEATHIITI
  1621  HCLNTPRWTS TQTSGPGLPI GFKGWNGQIF KVNTLLEPKV LSDDCKIQDG SWHKATFLFH
  1681  TQEPNQLPVI EVQKLPHLKT ERKYYIDSSS VCFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COL24A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

cervix: 6.6 nTPM
colon: 6.2 nTPM
urinary bladder: 5.3 nTPM
retina: 5.1 nTPM
hippocampal formation: 4.4 nTPM
cerebral cortex: 3.7 nTPM

Single-cell type

pdcs: 424 nCPM
thymocytes: 343 nCPM
hematopoietic stem cells: 329 nCPM
müller glia: 221 nCPM
brain excitatory neurons: 159 nCPM
melanocytes: 153 nCPM

Immune cell

plasmacytoid DC: 2.7 nTPM
NK-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 22 nTPM
hippocampal formation: 20 nTPM
basal ganglia: 8 nTPM
white matter: 7.6 nTPM
hypothalamus: 4.6 nTPM
amygdala: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

extracellular matrix structural constituent conferring tensile strength

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COL24A1 as an antibody target. Whether an autoantibody or antibody against COL24A1 could matter depends on whether native COL24A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COL24A1 is annotated as secreted, so native COL24A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COL24A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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