Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

Definition

This superfamily brings together catalytic domains found in Alpha-ketoglutarate-dependent dioxygenase AlkB-like DNA/RNA demethylases. AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron [[cite:PMID:12226668], [cite:PMID:21068844]]. The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases [[cite:PMID:16513174], [cite:PMID:24489119]]. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel PMID:19706517.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• ALKBH1
• ALKBH2
• ALKBH3
• ALKBH4
• ALKBH5
• ALKBH6
• ALKBH7
• FTO