ALKBH6
Probable RNA/DNA demethylase ALKBH6
Also known as: ALKB6_HUMAN, MGC15677
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q3KRA9
- Gene
- ALKBH6
- Ensembl
- ENSG00000239382
- Chromosome
- 19
- Canonical length
- 238 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Focal adhesion sites
OverviewNCBI Gene
Predicted to enable dioxygenase activity and metal ion binding activity. Located in focal adhesion and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
238 residues, UniProt reviewed canonical sequence.
>Q3KRA9|ALKBH6
1 MEEQDARVPA LEPFRVEQAP PVIYYVPDFI SKEEEEYLLR QVFNAPKPKW TQLSGRKLQN
61 WGGLPHPRGM VPERLPPWLQ RYVDKVSNLS LFGGLPANHV LVNQYLPGEG IMPHEDGPLY
121 YPTVSTISLG SHTVLDFYEP RRPEDDDPTE QPRPPPRPTT SLLLEPRSLL VLRGPAYTRL
181 LHGIAAARVD ALDAASSPPN AAACPSARPG ACLVRGTRVS LTIRRVPRVL RAGLLLGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ALKBH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 18 nTPM
- hypothalamus: 18 nTPM
- midbrain: 18 nTPM
- basal ganglia: 17 nTPM
- amygdala: 17 nTPM
- hippocampal formation: 16 nTPM
Single-cell type
- other brain neurons: 15 nCPM
- brain excitatory neurons: 12 nCPM
- brain inhibitory neurons: 12 nCPM
- astrocytes: 9.2 nCPM
- oligodendrocytes: 7.6 nCPM
- bergmann glia: 6.7 nCPM
Immune cell
- basophil: 57 nTPM
- eosinophil: 49 nTPM
- T-reg: 34 nTPM
- memory B-cell: 33 nTPM
- NK-cell: 30 nTPM
- gdT-cell: 27 nTPM
Brain region
- pons: 34 nTPM
- thalamus: 26 nTPM
- medulla oblongata: 26 nTPM
- hypothalamus: 26 nTPM
- cerebral cortex: 22 nTPM
- midbrain: 22 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 1.16
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Oxoglutarate/iron-dependent dioxygenase domain
- Alpha-ketoglutarate-dependent dioxygenase AlkB-like
- Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
- 2OG-Fe(II) oxygenase superfamily
- Alpha-ketoglutarate-dependent dioxygenase alkB homologue 6
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ALKBH6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ALKBH6 as an antibody target. Whether an autoantibody or antibody against ALKBH6 could matter depends on whether native ALKBH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ALKBH6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ALKBH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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