Seroatlas · Human Serome Atlas

ALKBH2

DNA oxidative demethylase ALKBH2

Also known as: ABH2, ALKB2_HUMAN, MGC90512

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NS38
Gene
ALKBH2
Ensembl
ENSG00000189046
Chromosome
12
Canonical length
261 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homotrimer

OverviewNCBI Gene

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q6NS38|ALKBH2
     1  MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI
    61  RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL
   121  TYTFSGLTLS PKPWIPVLER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP
   181  GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV
   241  RKKVLAPRVN LTFRKILLTK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALKBH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • liver: 31 nTPM
  • skin: 27 nTPM
  • skeletal muscle: 24 nTPM
  • endometrium: 22 nTPM
  • breast: 21 nTPM
  • adipose tissue: 21 nTPM

Single-cell type

  • oocytes: 111 nCPM
  • decidual stromal cells: 61 nCPM
  • esophageal basal cells: 49 nCPM
  • differentiating spermatogonia: 47 nCPM
  • basal keratinocytes: 42 nCPM
  • suprabasal keratinocytes: 41 nCPM

Immune cell

  • naive B-cell: 28 nTPM
  • memory B-cell: 28 nTPM
  • naive CD4 T-cell: 27 nTPM
  • MAIT T-cell: 22 nTPM
  • plasmacytoid DC: 22 nTPM
  • memory CD4 T-cell: 18 nTPM

Brain region

  • white matter: 20 nTPM
  • basal ganglia: 17 nTPM
  • pons: 16 nTPM
  • medulla oblongata: 16 nTPM
  • midbrain: 16 nTPM
  • thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALKBH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALKBH2 as an antibody target. Whether an autoantibody or antibody against ALKBH2 could matter depends on whether native ALKBH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALKBH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALKBH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALKBH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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