Seroatlas · Human Serome Atlas

ALKBH7

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Also known as: ALKB7_HUMAN, MGC10974, SPATA11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT30
Gene: ALKBH7
Ensembl: ENSG00000125652
Chromosome: 19
Canonical length: 221 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable dioxygenase activity and metal ion binding activity. Involved in DNA damage response and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q9BT30|ALKBH7
     1  MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR
    61  YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP
   121  HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL
   181  RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALKBH7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 518 nTPM

Expression across tissuesHPA

Tissue

testis: 518 nTPM
liver: 163 nTPM
heart muscle: 159 nTPM
skeletal muscle: 145 nTPM
pancreas: 112 nTPM
kidney: 94 nTPM

Single-cell type

late spermatids: 13,357 nCPM
late primary spermatocytes: 3,371 nCPM
early spermatids: 2,932 nCPM
enterocytes: 770 nCPM
colonocytes: 545 nCPM
esophageal apical cells: 484 nCPM

Immune cell

plasmacytoid DC: 144 nTPM
naive CD4 T-cell: 138 nTPM
myeloid DC: 128 nTPM
memory B-cell: 114 nTPM
naive CD8 T-cell: 112 nTPM
classical monocyte: 107 nTPM

Brain region

choroid plexus: 78 nTPM
white matter: 74 nTPM
cerebellum: 70 nTPM
spinal cord: 66 nTPM
medulla oblongata: 66 nTPM
thalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
2OG-Fe(II) oxygenase superfamily
Alpha-ketoglutarate-dependent dioxygenase alkB homologue 7-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALKBH7 as an antibody target. Whether an autoantibody or antibody against ALKBH7 could matter depends on whether native ALKBH7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALKBH7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALKBH7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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