Pancreatic trypsin inhibitor Kunitz domain superfamily
IPR036880
Definition
The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family PMID:14705960 and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) α/β proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) PMID:1714504 (or basic protease inhibitor), but the family includes numerous other members [[cite:PMID:1703675], [cite:PMID:1593645], [cite:PMID:8159751], [cite:PMID:1304909]], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rodent mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor. The pancreatic trypsin inhibitor (Kunitz) family [[cite:PMID:6996568], [cite:PMID:1703675], [cite:PMID:1593645]] is one of the numerous families of serine proteinase inhibitors. The basic structure of such a type of inhibitor is shown in the following schematic representation: +-----------------------+ | +--------+ | | | **|******* | xxCxxC#xxxCxxxCxxxxxxCxxxxCxx | | +----------+ {------50 residues------} 'C': conserved cysteine involved in a disulfide bond. '#': active site residue. '*': position of the pattern.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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