Seroatlas · Human Serome Atlas

MOB3C

MOB kinase activator 3C

Also known as: MOB1E, MOB3C_HUMAN, MOBKL2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q70IA8
Gene: MOB3C
Ensembl: ENSG00000142961
Chromosome: 1
Canonical length: 216 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q70IA8|MOB3C
     1  MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL PPGENIDDWI
    61  AVHVVDFFNR INLIYGTMAE RCSETSCPVM AGGPRYEYRW QDERQYRRPA KLSAPRYMAL
   121  LMDWIEGLIN DEEVFPTRVG VPFPKNFQQV CTKILTRLFR VFVHVYIHHF DSILSMGAEA
   181  HVNTCYKHFY YFIREFSLVD QRELEPLREM TERICH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

tongue: 47 nTPM
pancreas: 38 nTPM
skeletal muscle: 24 nTPM
adipose tissue: 21 nTPM
urinary bladder: 20 nTPM
spleen: 19 nTPM

Single-cell type

platelets: 7.1 nCPM
kupffer cells: 1 nCPM
breast myoepithelial cells: 0.9 nCPM
megakaryocyte progenitors: 0.9 nCPM
urothelial cells: 0.5 nCPM
breast lactating cells: 0.4 nCPM

Immune cell

MAIT T-cell: 28 nTPM
eosinophil: 23 nTPM
NK-cell: 23 nTPM
total PBMC: 17 nTPM
memory CD8 T-cell: 16 nTPM
gdT-cell: 16 nTPM

Brain region

cerebellum: 21 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 16 nTPM
pons: 16 nTPM
basal ganglia: 14 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB3C as an antibody target. Whether an autoantibody or antibody against MOB3C could matter depends on whether native MOB3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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