Seroatlas · Human Serome Atlas

MOB3A

MOB kinase activator 3A

Also known as: MOB-LAK, MOB1C, MOB3A_HUMAN, MOBKL2A, moblak

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BX8
Gene: MOB3A
Ensembl: ENSG00000172081
Chromosome: 19
Canonical length: 217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q96BX8|MOB3A
     1  MSNPFLKQVF NKDKTFRPKR KFEPGTQRFE LHKKAQASLN AGLDLRLAVQ LPPGEDLNDW
    61  VAVHVVDFFN RVNLIYGTIS DGCTEQSCPV MSGGPKYEYR WQDEHKFRKP TALSAPRYMD
   121  LLMDWIEAQI NNEDLFPTNV GTPFPKNFLQ TVRKILSRLF RVFVHVYIHH FDRIAQMGSE
   181  AHVNTCYKHF YYFVKEFGLI DTKELEPLKE MTARMCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

lymph node: 68 nTPM
tonsil: 61 nTPM
spleen: 58 nTPM
bone marrow: 50 nTPM
appendix: 47 nTPM
colon: 34 nTPM

Single-cell type

neutrophils: 496 nCPM
monocytes: 212 nCPM
cdc: 209 nCPM
b-cells: 143 nCPM
extravillous trophoblasts: 118 nCPM
macrophages: 117 nCPM

Immune cell

neutrophil: 275 nTPM
eosinophil: 101 nTPM
non-classical monocyte: 97 nTPM
classical monocyte: 87 nTPM
total PBMC: 86 nTPM
intermediate monocyte: 84 nTPM

Brain region

cerebral cortex: 96 nTPM
medulla oblongata: 54 nTPM
thalamus: 51 nTPM
pons: 45 nTPM
choroid plexus: 43 nTPM
midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.64
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB3A as an antibody target. Whether an autoantibody or antibody against MOB3A could matter depends on whether native MOB3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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