Seroatlas · Human Serome Atlas

MOB3B

MOB kinase activator 3B

Also known as: C9orf35, FLJ13204, MOB1D, MOB3B_HUMAN, MOBKL2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TA1
Gene: MOB3B
Ensembl: ENSG00000120162
Chromosome: 9
Canonical length: 216 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q86TA1|MOB3B
     1  MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL PSGEDQNDWV
    61  AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW QDDLKYKKPT ALPAPQYMNL
   121  LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI CKKILCRLFR VFVHVYIHHF DRVIVMGAEA
   181  HVNTCYKHFY YFVTEMNLID RKELEPLKEM TSRMCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 31 nTPM
ovary: 18 nTPM
duodenum: 17 nTPM
small intestine: 15 nTPM
rectum: 12 nTPM
midbrain: 12 nTPM

Single-cell type

oligodendrocytes: 639 nCPM
müller glia: 363 nCPM
bergmann glia: 324 nCPM
choroid plexus epithelial cells: 271 nCPM
ovarian stromal cells: 224 nCPM
brain inhibitory neurons: 221 nCPM

Immune cell

naive B-cell: 2.9 nTPM
myeloid DC: 2.7 nTPM
memory B-cell: 2.5 nTPM
intermediate monocyte: 0.8 nTPM
classical monocyte: 0.5 nTPM
non-classical monocyte: 0.5 nTPM

Brain region

white matter: 62 nTPM
medulla oblongata: 50 nTPM
basal ganglia: 49 nTPM
cerebellum: 41 nTPM
midbrain: 41 nTPM
spinal cord: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.02
gnomAD missense Z: 1.12
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB3B as an antibody target. Whether an autoantibody or antibody against MOB3B could matter depends on whether native MOB3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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