MIT domain superfamily
IPR036181
Definition
This entry represents the MIT domain superfamily. The MIT domain forms an asymmetric three-helix bundle. It is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. A 'variant' MIT domain has been described at the N-terminal region of a related AAA-ATPase, mammalian katanin p60 PMID:20339000. The MIT domain has a Spectrin repeat-like fold. This fold is composed of three helices in a close bundle topology. It has also a left-handed twist going up-and-down PMID:16018968.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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