Seroatlas · Human Serome Atlas

ULK3

Serine/threonine-protein kinase ULK3

Also known as: DKFZP434C131, FLJ90566, ULK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PHR2
Gene
ULK3
Ensembl
ENSG00000140474
Chromosome
15
Canonical length
472 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Acrosome

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q6PHR2|ULK3
     1  MAGPGWGPPR LDGFILTERL GSGTYATVYK AYAKKDTREV VAIKCVAKKS LNKASVENLL
    61  TEIEILKGIR HPHIVQLKDF QWDSDNIYLI MEFCAGGDLS RFIHTRRILP EKVARVFMQQ
   121  LASALQFLHE RNISHLDLKP QNILLSSLEK PHLKLADFGF AQHMSPWDEK HVLRGSPLYM
   181  APEMVCQRQY DARVDLWSMG VILYEALFGQ PPFASRSFSE LEEKIRSNRV IELPLRPLLS
   241  RDCRDLLQRL LERDPSRRIS FQDFFAHPWV DLEHMPSGES LGRATALVVQ AVKKDQEGDS
   301  AAALSLYCKA LDFFVPALHY EVDAQRKEAI KAKVGQYVSR AEELKAIVSS SNQALLRQGT
   361  SARDLLREMA RDKPRLLAAL EVASAAMAKE EAAGGEQDAL DLYQHSLGEL LLLLAAEPPG
   421  RRRELLHTEV QNLMARAEYL KEQVKMRESR WEADTLDKEG LSESVRSSCT LQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ULK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 31 nTPM
  • esophagus: 29 nTPM
  • skin: 23 nTPM
  • cerebral cortex: 22 nTPM
  • skeletal muscle: 20 nTPM
  • basal ganglia: 18 nTPM

Single-cell type

  • esophageal apical cells: 259 nCPM
  • retinal amacrine cells: 93 nCPM
  • enterocytes: 60 nCPM
  • brain excitatory neurons: 59 nCPM
  • tuft cells: 58 nCPM
  • brain inhibitory neurons: 57 nCPM

Immune cell

  • gdT-cell: 11 nTPM
  • T-reg: 9.2 nTPM
  • memory CD8 T-cell: 9 nTPM
  • MAIT T-cell: 8.7 nTPM
  • intermediate monocyte: 7.2 nTPM
  • naive CD4 T-cell: 7.1 nTPM

Brain region

  • pons: 35 nTPM
  • cerebral cortex: 26 nTPM
  • white matter: 22 nTPM
  • basal ganglia: 20 nTPM
  • medulla oblongata: 20 nTPM
  • cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
1.24
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ULK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ULK3 as an antibody target. Whether an autoantibody or antibody against ULK3 could matter depends on whether native ULK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ULK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ULK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ULK3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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