FBXO9

Protein identityUniProt · HPA

UniProt accession

Q9UK97

Gene

FBXO9

Ensembl

ENSG00000112146

Chromosome

6

Canonical length

447 aa

Protein class

Predicted intracellular proteins

Subcellular location

Centrosome

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9UK97|FBXO9
     1  MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS
    61  SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA
   121  MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE
   181  LESSQIHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV
   241  WGRSCIKLVP YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI
   301  RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE
   361  EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS
   421  AFEIDKMYTP LFFARVRSYT AFSERPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

123 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0

gnomAD missense Z

1.71

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fat cell differentiation
• innate immune response
• proteasome-mediated ubiquitin-dependent protein catabolic process
• protein K48-linked ubiquitination
• protein ubiquitination
• regulation of TOR signaling
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Molecular functions

• ubiquitin-like ligase-substrate adaptor activity
• ubiquitin-protein transferase activity

Cellular components

• cytoplasm
• cytosol
• SCF ubiquitin ligase complex
• ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• F-box-like domain superfamily
• MIT domain superfamily
• F-box-like
• F-box protein Hrt3/FBXO9, C-terminal
• F-box only protein C-terminal region

KeywordsUniProt

• Cytoplasm
• Phosphoprotein
• TPR repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TELO2
• TTI1
• SKP1